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Technology Changes Lives. There Are New Advances In Yeast Research
- Oct 16, 2018 -

Tianjin university has made new progress in the analysis of yeast population genomics as follows


DNA double strand breaks can lead to chromosome breakage and cell death, while improper repair can lead to a series of problems such as gene mutation, insertion, deletion, translocation, even chromosome structure or number abnormality and out-of-control genomic stability.Therefore, the cells have evolved many DNA repair systems, in which the homologous recombination takes the homologous sequence as the template, which can accurately repair the DNA double strand break.Which biological functions or path-related sequences are highly dependent on homologous recombinant repair?At present, people's understanding of this problem is very limited.Tianjin university has recently made a breakthrough in this regard.


Based on the analysis of population genomics restructuring, science professor at tianjin university, tianjin university professor biological information center peak group found recombinant DNA double chain fracture of gene significantly in specific diseases and fitness related biological pathways, show that homologous recombination in diseases associated with environmental adaptability of double-stranded DNA has played a very important role in the fracture repair.The study sheds new light on the biological significance of homologous recombinant repair of eukaryotes, and because yeasts and humans are highly conservative in many biological mechanisms, it could also help develop new treatment strategies for specific human diseases.Looking ahead, this discovery may have broad application prospects in the treatment of nervous system diseases such as alzheimer's disease and Parkinson's disease, metabolic diseases such as non-alcoholic fatty liver disease and drug metabolism.