Tianjin university has made new progress in the analysis of yeast population genomics as follows:
DNA double strand breaks can lead to chromosome breakage and cell death, while improper repair can lead to a series of problems such as gene mutation, insertion, deletion, translocation, even chromosome structure or number abnormality and out-of-control genomic stability.Therefore, the cells have evolved many DNA repair systems, in which the homologous recombination takes the homologous sequence as the template, which can accurately repair the DNA double strand break.Which biological functions or path-related sequences are highly dependent on homologous recombinant repair?At present, people's understanding of this problem is very limited.Tianjin university has recently made a breakthrough in this regard.
Based on the analysis of population genomics restructuring, science professor at tianjin university, tianjin university professor biological information center peak group found recombinant DNA double chain fracture of gene significantly in specific diseases and fitness related biological pathways, show that homologous recombination in diseases associated with environmental adaptability of double-stranded DNA has played a very important role in the fracture repair.The study sheds new light on the biological significance of homologous recombinant repair of eukaryotes, and because yeasts and humans are highly conservative in many biological mechanisms, it could also help develop new treatment strategies for specific human diseases.Looking ahead, this discovery may have broad application prospects in the treatment of nervous system diseases such as alzheimer's disease and Parkinson's disease, metabolic diseases such as non-alcoholic fatty liver disease and drug metabolism.
In addition, professor gao's research group has previously conducted bioinformatics analysis on the genomes of nearly 100 strains of saccharomyces cerevisiae widely distributed around the world, and detected the super-conserved sequence within the species of saccharomyces cerevisiae.Functional analysis of the super-conserved sequences showed that these sequences not only participate in the basic biological functions of saccharomyces cerevisiae, but also participate in the biological pathways of cell's acid secretion, nutrient perception and transport.This indicates that during the long evolution process, saccharomyces cerevisiae maintained its strong adaptability to acid stress and excellent ability of nutrition perception and transport through super conservative molecular mechanism.
The findings were published in bioinformatics, a leading journal in the field of bioinformatics.Yang zhikai, a doctoral student at the university of science and technology, is the first author of the two papers, and gao is the corresponding author.Peak in the yeast genome research, as a system engineering, a professor at the ministry of education key laboratory of collaborative innovation center, tianjin chemical engineering "synthetic biology technology research platform" and "synthetic biology and biological process" by the national natural Science foundation of innovation backbone members, also involved in the synthesis of saccharomyces cerevisiae genome plan, as co-authors in the journal Science published yeast genome chromosome 10 synthetic work.
He has published more than 50 papers in journals such as Science.Among them, 36 SCI papers by the first (newsletter) authors were published in international renowned academic journals such as Nucleic acids research, PNAS and Bioinformatics(5), and were cited by journals such as Science, Nature and Nature Biotechnology.Currently serves as an expert member of F1000Prime (F1000Prime:Faculty Member), associate editor of the journal Frontiers in Microbiology and Frontiers in Genetics, SCI journal editors such as Briefings in Bioinformatics, Genomics Proteomics & Bioinformatics and Scientific Reports,Chinese society for cell biology functional genomics and bioinformatics and systems biology branch of director of the Chinese society of genetic biological data of the professional committee, etc, also served as the ministry of education of science and technology award, the ministry of education degree and graduate education development center of the fourth round of discipline evaluation communication evaluation experts and research and development of the national key program biosafety focus on special budget administrator sig gissler experts, etc.
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