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The Sequence Composition of Yeast
- Sep 28, 2018 -

Before the saccharomyces cerevisiae sequencing project began, about 2,600 genes that encode RNA or proteins in yeast had been identified through conventional genetic methods.Through the complete genome sequencing of the saccharomyces cerevisiae, it was found that there were 5,885 open reading frames encoding specific proteins in the whole genome sequence of 12068kb.


This means that an average of one protein-coding gene is present in the yeast genome every 2kb, meaning that 72% of the nucleotide sequences in the entire genome are made up of open reading frames.This suggests that yeast genes are more tightly packed than those of other higher eukaryotes.For example, in the nematode genome, there is a protein-coding gene every 6kb.A protein-coding gene is found in the human genome at an average of 30kb or more.The tightness of the yeast genome is due to the short spacing between the genes and the lack of introns in the genes.The average length of the open reading frame of the yeast genome is 1450bp, or 483 codons. 

The longest is an unknown open reading frame (4910 codons) located on chromosome XII, with a very small number of open reading frames exceeding 1,500 codons.In the yeast genome, there are also genes that encode short proteins, such as PMP1, a cytoplasmic membrane protein made up of 40 amino acids.In addition, the yeast genome contains about 140 RNA coding genes arranged at the long end of chromosome XII.40 snrna-coding genes, spread on 16 chromosomes;275 tRNA genes belonging to 43 families are also widely distributed in the genome.

Sep.28, 2018

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